In-silico molecular docking analysis of some plant derived molecules for anti-inflammatory inhibitory activity

Herbs are essential resources for drug discovery. However, numerous challenges stand in front of the scientific community to discover novel drugs from herbs. To explore validation behind precious knowledge traditional medicine, we focused on achieving virtual screening detect potential medicines Five bioactive compounds known anti-inflammatory medicinal plants were examined through molecular docking against cyclooxygenase-2 (COX-2) and inducible Nitric Oxide Synthase (iNOS), using AutoDock 4.2. The selected ligands with COX-2 showed binding energy varying -6.15 Kcal/mol ‑11.24 Kcal/mol. energies identified iNOS generated ranges -3.85kcal/mol -6.99 kcal/mol. Among tested ligands, it was noted that 6 urs-12-en-24-oic acid best than other lowest highest affinity both target proteins iNOS. silico study validates phytochemical compound herb contribute activity low toxicity minimal side effects.